In silico network and pathway enrichment analysis. Lists of the proteins in the CRBN complex that upregulated (A) or downregulated (B) in response to lenolidomide were evaluated against the latest versions of the following databases (covering >50% of human proteins): CellMap, Reactome, KEGG, NCI-PID, and BioCartel. Linker genes were included in the network modeling and pathway enrichment predictions. Results were filtered for a P value < .05 and a false discovery rate < 0.05. The separate networks modeled from downregulation vs upregulation lists are presented in (A) and (B), and the association or connection between IKZF1 and CRBN was a custom annotation added to the figures.