Gene expression analysis of IKZF1 and IKZF3 across cell lines originated from multiple hematological and solid tumors. The number of cases of each tumor entity is indicated in parenthesis. Red boxes indicate the set of MM cell lines. Results show IKZF1 (A) and IKZF3 (B) expression in most cell lines established from hematological tumors. The findings in hematological neoplasms contrast with the lack of expression of both genes found in solid-tumor cell lines. AML, acute myeloid leukemia; B-ALL, B-cell acute lymphoblastic leukemia; CML, chronic myeloid leukemia; T-ALL, T-cell acute lymphoblastic leukemia; MCL, mantle cell lymphoma; DLBCL, diffuse large B-cell lymphoma; MM, multiple myeloma.^26,27