Comparison of age of onset, CD107a degranulation, and perforin expression. Percentage of patients with (A) early age of onset (≤24 months), (B) degranulation based on CD107a expression, and (C) perforin expression levels were compared among the groups. Patients were grouped as Affected (homozygous or compound heterozygous), Single heterozygotes, or Double heterozygotes and then further separated on the basis of the genes affected, as shown by the color bar and the dotted lines between groups.