Enhancer targeting strategies with proven therapeutical potential. (A) Deletion of enhancers can cell type specifically modulate disease-associated gene expression. (B) Artificial tethering of TFs to regulatory elements can restore disease-impaired chromatin looping, leading to reactivation of gene expression. Similar tethering strategies can also be used to artificially reactivate naturally silenced genes for therapeutic use⁷⁴  or for enhancer silencing by tethering inhibitory proteins to the enhancer.⁷⁰