Figure 3
![Figure 3. Association of HLA-DRB1 and HLA-DQB1 alleles with asparaginase hypersensitivity. Using a general linear model adjusted for gender, age, treatment arm, and ALL immunophenotype, (A) HLA-DRB1*07:01 (P = .001 [Padjusted = .023]) was associated with asparaginase hypersensitivities within the discovery cohort (n = 541). The dashed horizontal red line identifies a permuted significance threshold of P < .05 that is adjusted for multiple testing. Patients with the HLA-DRB1*07:01 allele had a higher incidence of hypersensitivity compared with patients that did not have the allele within the (B) discovery cohort (n = 541), (C) validation cohort (n = 1329), and (D) the combined cohort (n = 1870).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/8/10.1182_blood-2014-03-563742/4/1266f3.jpeg?Expires=1735850228&Signature=U3~XZa-LBCXRnToV3c43oYmfG6phxEZhtEPDaairSEspNd0NEOQpHx77JbjCS8vg3b~ok2WrKwk1ZdCwmcKsDq7MK8I~ro7DIATHIIRy74650C9frbRxxWs8GKPMIe0wDzxJwqMvABbZgWRLwP6BERzdC0MNXiLi~skBOlsUWl~iVj0tvoU~NMAa3PxK2ouflVncaJ7jLZTzOfTaSP5oJPVslUVQLH3oaiHeVDuCPQeTQfH2YUMUi4or-WZxbGEtnPU2Q1cMccHYR5NSLZ5hCx-Ifoj7IWk-fvHNe9l5amFqX7~HcFCb0zzdmXivQnlb5Wq1B6kZ9eS533X9m6yzDw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Association of HLA-DRB1 and HLA-DQB1 alleles with asparaginase hypersensitivity. Using a general linear model adjusted for gender, age, treatment arm, and ALL immunophenotype, (A) HLA-DRB1*07:01 (P = .001 [Padjusted = .023]) was associated with asparaginase hypersensitivities within the discovery cohort (n = 541). The dashed horizontal red line identifies a permuted significance threshold of P < .05 that is adjusted for multiple testing. Patients with the HLA-DRB1*07:01 allele had a higher incidence of hypersensitivity compared with patients that did not have the allele within the (B) discovery cohort (n = 541), (C) validation cohort (n = 1329), and (D) the combined cohort (n = 1870).
