Outcomes in patients with ALCL based on genetic subtype. (A) OS rates in patients with ALCL, stratified by ALK status only (ALK positive, N = 29; ALK negative, N = 67). (B) OS rates in patients with ALCL, stratified by rearrangements of ALK (N = 29), DUSP22 (N = 21), and TP63 (N = 6). ^−/−/−, triple-negative cases lacking all 3 rearrangements (N = 40). (C) OS rates in patients with ALCL who did not undergo transplantation, stratified by rearrangements of ALK (N = 21), DUSP22 (N = 15), and TP63 (N = 5). ^−/−/−, N = 34.