FFS after systemic treatment of chronic GVHD. (A) initial treatment, (B) second-line treatment. The dark gray area represents treatment failure due to recurrent malignancy. The light gray area represents treatment failure due to nonrelapse mortality (NRM), and the black area represents treatment failure due to treatment change. The white area represents FFS. The dashed line represents cumulative incidence of successful withdrawal of all systemic IST during initial treatment.