Figure 2
![Figure 2. Study of novel pathogenic mechanisms of CLL in the TCL1-driven leukemia model. Overexpression (transgenic [tg]) or deficiency of different molecules in the Eμ-TCL1 transgenic mouse model variably affects the disease phenotype (BM, bone marrow; TAM, tumor-associated macrophages). The following mouse models have been crossed with Eμ-TCL1 mice: xid,91 pkcβ−/− (or pkcβ+/−),70 xbp1fl/flCD19-Cre,73 tir8−/−,72 dnrag1-tg,71 hs1−/−,79 rhoh−/−,59,80 p53−/−,75 id4−/−,76 miR29a/b-tg,35 fzd6−/−,89 cd44−/−,87 mif−/−,86 ROR1-tg,34 APRIL-tg,85 and baff-tg.84](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/7/10.1182_blood-2014-05-577122/5/1010f2.jpeg?Expires=1735814500&Signature=HPL8XdRJfq4xWPYKX4JugK~6YuypQ0uhDp-~hOqhYAWCRJyWfQm5S5eSUhzsN0mVYWGuuMcXyNPgWA5gtG14wSWoQdPLR68Qipz5Y~JtxXSDJczYZoUSk7lrodcDZry6ZPOkhvRpVAll4JJHQM-tav85EMJa63Q90BETa1hhH7IOWarsWWHk83ZLNul7h2W5W2XrHU2fn~Xrgu3dADvW1kyZVQGFFklh9VNpgxk-gSOWFU49Ukbx9CSDfNwjB4bIhIxPO1jECsGW-VFET-uiAvY~Y-IMPprYsCoghybMgISi6NhuM-RIuR9JiezgqBTE-mAX2RrbQbaiPvOwdraFvQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Study of novel pathogenic mechanisms of CLL in the TCL1-driven leukemia model. Overexpression (transgenic [tg]) or deficiency of different molecules in the Eμ-TCL1 transgenic mouse model variably affects the disease phenotype (BM, bone marrow; TAM, tumor-associated macrophages). The following mouse models have been crossed with Eμ-TCL1 mice: xid,91 pkcβ−/− (or pkcβ+/−),70 xbp1fl/flCD19-Cre,73 tir8−/−,72 dnrag1-tg,71 hs1−/−,79 rhoh−/−,59,80 p53−/−,75 id4−/−,76 miR29a/b-tg,35 fzd6−/−,89 cd44−/−,87 mif−/−,86 ROR1-tg,34 APRIL-tg,85 and baff-tg.84
