MM subentities defined by SNP array. In this picture of 192 patients with MM at diagnosis, several subgroups can be identified: monosomies 13 and 14 and frequent 1p deletions (1); monosomies 13 and 1q gains (2); hyperdiploidy (3); and within hyperdiploidy, patients with monosomies 13 and lack of trisomy 11 (4). Adapted from Avet-Loiseau et al30 with permission.