Megakaryocyte RNA-seq. (A) Hierarchical clustered heat map with scaled Z-score color key of normalized counts of 833 differentially expressed genes in 3 WT^lox and 3 dKO samples. Samples with the same genotype are indicated by black (WT^lox) and red (dKO) horizontal bars; gene clusters are indicated by red (upregulated in dKO) and cyan (downregulated in dKO) vertical bars. (B) Transcription factor binding sites enrichment detected, using HOMER, in promoters of 454 downregulated genes in dKO with a threshold FDR <0.01. (C) Transcription factor binding sites enrichment detected, using HOMER, in promoters of 379 upregulated genes in dKO with a threshold FDR <0.01.