Platelet proteomics with integrative RNA-seq analysis. (A) Hierarchical clustered heat map with scaled Z-score color key of log₂ transformed label-free quantification (LFQ) intensities of 85 differentially expressed proteins in 4 WT^lox and 4 dKO platelet lysate samples. Samples with the same genotype are indicated by black (WT^lox) and red (dKO) horizontal bars and protein expression clusters are indicated by red (upregulated in dKO) and cyan (downregulated in dKO) vertical bar. (B) Scatterplot of differentially expressed proteins in platelets (mass spectrometry) and differentially expressed genes in megakaryocytes (RNA-seq) in dKO samples with n = 106. MS, mass spectrometry.