Algorithm illustrating the classification process based on morphologic and genetic criteria identified by the unsupervised clustering analyses. According to these analyses, the threshold of 5% BM blasts retains a significant discriminant value, irrespective of the underlying driver mutation pattern. In MDS with no excess blasts, the presence of isolated del(5q), SF3B1 mutation or multilineage dysplasia-associated mutations recognize genetically-defined disease subtypes.