Figure 3
![Figure 3. BMT reduced the oxidative stress response and prevented injury to Hmox1−/− kidneys. mRNA levels of oxidative stress responsive genes were significantly elevated in KO Ctr animals, including Gsta2 (glutamine-S-transferase A2) (A), Gstm1 (glutamine-S-transferase μ 1) (B), Gclc (glutamate-cysteine ligase, catalytic subunit) (C), Nqo1 [NAD(P)H:quinone dehydrogenase, quinone 1] (D), Fpn1 (ferroportin 1) (E), and Mrp2 (F), but returned to normal after BMT. (G) Masson’s trichrome staining of paraffin-embedded kidney tissues revealed significant accumulation of collagen, which is colored blue (arrows) in KO Ctr mice. Collagen depositions were minimal in transplanted animals. Scale bar represents 50 μm.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/9/10.1182_blood-2014-02-554162/4/1522f3.jpeg?Expires=1735509511&Signature=FGwACP78C6Y7H6Ud1ExX3MbRtyeA2K216qVRe6gbuxbGkXmX2TdSL0rRrUuO3HKTyytK1eKYfM8QcCRbcxiR5op5WeuFp-jc7enCr0lGP9DVJZryAkQNYEUAfDoC674ndleoUGBjuk-Wr4UCw7taCQlrFiVzhSvjFn272zvoSw6MBxuWC9H3RZl33PttuuB9GCwONDYhUjMX5AKrzEB-6skWp1tSZeY2DhMCVBxvD~MfpCfQl2ZBJboPQjeKqcMRdhrThtiecq3vtjhwXpgCESXaLHtd--RcyNunmmqF6iRM9MgAfkRuVT65LPMYhz6Q2YOX46R08RsLYajy~FrVkw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
BMT reduced the oxidative stress response and prevented injury to Hmox1−/− kidneys. mRNA levels of oxidative stress responsive genes were significantly elevated in KO Ctr animals, including Gsta2 (glutamine-S-transferase A2) (A), Gstm1 (glutamine-S-transferase μ 1) (B), Gclc (glutamate-cysteine ligase, catalytic subunit) (C), Nqo1 [NAD(P)H:quinone dehydrogenase, quinone 1] (D), Fpn1 (ferroportin 1) (E), and Mrp2 (F), but returned to normal after BMT. (G) Masson’s trichrome staining of paraffin-embedded kidney tissues revealed significant accumulation of collagen, which is colored blue (arrows) in KO Ctr mice. Collagen depositions were minimal in transplanted animals. Scale bar represents 50 μm.
