Figure 1
![Figure 1. Structure of the recombinant proteins used in this study. All proteins have a Gla domain, 2 epidermal growth factor (EGF) domains (EGF-1 and EGF-2), and a catalytic domain. A recognition site (Arg-Lys-Arg-Arg-Lys-Arg [RKRRKR]) for a paired amino acid cleaving enzyme (PACE)/furin type protease is inserted after the Arg at position 152. The sequence of the Gla domain is shown and highlighted in blue for each protein. Changes in the Gla domain compared with mFVIIa taken from the mouse PC Gla domain are highlighted in orange. Numbering refers to the mature form of each protein.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/124/7/10.1182_blood-2014-04-567297/5/1157f1.jpeg?Expires=1735817295&Signature=Xs83dpe-Vms8ulLK0ysGOTTSapODVt15rCRO~ZuWMJagJlEdw8XabtaOPvnX-0RhWGMWKRgXkfUy0x6w4bXdocYET3CrKJlknaepuRn~pxrEqEFusbem7GSen3TI2Q2LermyKF1N7PZi2zDbjuS-OkWw760vUvAgFjnn0ljPZeEVY1jodjpVHqzjgJVTgecn8PbZ-rtHS5CbRCLFaQOD~gbuOq24uNfauc68Sccxfv4Uihxh0KkMGRVFr-W4FBPKxAjMlRIEHl~ZDfCKxMebmvGZaKCr-yRk101f6flNLPBNQkDG~L9xQO89qEq9OJB-5~52aG0qcJRbZWmwltWTeA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Structure of the recombinant proteins used in this study. All proteins have a Gla domain, 2 epidermal growth factor (EGF) domains (EGF-1 and EGF-2), and a catalytic domain. A recognition site (Arg-Lys-Arg-Arg-Lys-Arg [RKRRKR]) for a paired amino acid cleaving enzyme (PACE)/furin type protease is inserted after the Arg at position 152. The sequence of the Gla domain is shown and highlighted in blue for each protein. Changes in the Gla domain compared with mFVIIa taken from the mouse PC Gla domain are highlighted in orange. Numbering refers to the mature form of each protein.
