Adult 18- to 20-week-old Moz^+/− mice display a significant reduction in B-cell progenitors. (A) Femur, spleen, and thymus cellularity of Moz^+/− and WT mice. (B) Spleen and thymus weights relative to overall body weight. (C) Quantification of HSC and early hematopoietic progenitors in the BM. (D) Enumeration of B-cell progenitors in the BM. (E) B-cell subset numbers in the spleen. (F) Quantification of B-cell numbers in the peripheral blood. (G) Schematic of T-cell development. CLPs give rise to DN1 cells, which via DN2, DN3, and DN4 intermediaries produce CD4/CD8 double-positive cells. Single CD4⁺ and CD8⁺ cells are derived from double-positive cells. (H) Enumeration of T-cell progenitors and CD4⁺ and CD8⁺ cells in the thymus. (I) Quantification of T cells in the peripheral blood. (J) Schematic of myeloid, erythrocyte, and megakaryocyte development. (K) Numbers of CLPs, MEPs, and GMPs in the BM. (L) Quantification of erythrocyte progenitors in the BM. (M) Enumeration of myeloid cells and megakaryocytes in the BM. (N) Numbers of myeloid cells in the peripheral blood. Data above are presented as mean ± SEM. Asterisks indicate a statistically significant difference between Moz^+/− and WT at *P < .05, **P < .01, and ***P < .001. Cell surface markers used to discriminate between these cell populations are outlined in supplemental Table 9. CMP, common myeloid progenitor; DN, double-negative; Ery, erythrocyte; GMP, granulocyte macrophage progenitor; LSK, lineage negative, Sca-1 positive, c-KIT positive population; LT-HSC, long-term HSC; Meg, megakaryocyte; MEP, megakaryocyte erythrocyte progenitor; MGZ, marginal zone B cells; MPP, multipotent progenitor; ST-HSC, short-term HSC; T1/T2, transitory 1/2 B-cells.