Transcriptional profiling of poly(I:C) treated and untreated Cdk6^−/− HSCs. (A) A summary of transcripts up- (red) or down- (green) regulated (fold-change >2) in fraction A cells that were FACS-purified from either untreated or poly(I:C)-treated Cdk6^−/− and Cdk6^+/+ mice (n = 3 per genotype). (B) Transcripts deregulated in either untreated or poly(I:C)-treated Cdk6^−/− fraction A cells displayed promoter sequences significantly enriched in recognition sites for the indicated transcription factors compared with the respective Cdk6^+/+ controls. (C) GeneMANIA-computed association network of the transcription factors identified via their deregulated target gene programs in poly(I:C)-treated Cdk6^−/− fraction A cells vs Cdk6^+/+ controls.