![Donor T cells stimulated by alloantigens secrete IFN-γ, which stimulates host lung parenchyma to produce IL-6. Calcineurin inhibitors (such as cyclosporin [CsA]) suppress donor T-cell production of IFN-γ. IL-6 promotes Th17 differentiation of alloreactive T cells, which induces apoptosis by secreting IL-17 and promotes migration of macrophages into the lung, inducing IPS. Professional illustration by Patrick Lane, ScEYEnce Studios.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/125/15/10.1182_blood-2015-02-629816/4/2320f1.jpeg?Expires=1736054608&Signature=m716HvHqIT5dj-i5r~9QxSOVn8GTXoiAveZMtxURhhIQAk-pq6BDZvQH39JjUU7l3Nj9H6JBE1k~rsuglF6Ffht8BA~H3zyosD4ahoKqC8aQk2jCmqc1-M~wt2pwZsVH3aFU6Msts3cz8cZi42vcL7~fuouGaEFy~vz85qxeXlhoZIsHaxdeIxC3xoCuRktfQOM9ImSTwJ4QYt2PYURh-LxCvt7j1xIZcNjX5USbSdZ1-~qA7IihcxqvCit4xUE1SoakY1jUpocQTcZOdDHXlR8OkrjqEfb60pE7JUiTQceW3baKwZ9lJw4AHjBD0~80c0W5jlCDKfxVkTIxyiw2GA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Donor T cells stimulated by alloantigens secrete IFN-γ, which stimulates host lung parenchyma to produce IL-6. Calcineurin inhibitors (such as cyclosporin [CsA]) suppress donor T-cell production of IFN-γ. IL-6 promotes Th17 differentiation of alloreactive T cells, which induces apoptosis by secreting IL-17 and promotes migration of macrophages into the lung, inducing IPS. Professional illustration by Patrick Lane, ScEYEnce Studios.
