Correlation of the C3 levels of the aHUS patients with C3 mutations with the renal outcome. (A) Data from the French cohort. C3 levels of the patients who developed ESRD up to 1 year after the onset (n = 17) were compared with the rest of the patients (n = 13). Dashed line represents the cutoff for the lower normal range for the C3 levels in the French cohort (660 mg/L). Mean ± standard deviation was 704.9 ± 326.4 for the group of no ESRD 1 year after the onset and 501.7 ± 142.3 for the ESRD group. (B) Combined data from all identified cases in the literature. C3 levels for patients with C3 mutations and with ESRD (n = 26) or without ESRD (n = 41). Lower dashed line represents the cutoff for the lower normal range for the C3 levels as measured in plasma in the French normal population (660 mg/L). Higher dashed line is the cutoff for the lower normal range for the C3 levels in the Italian cohort (830 mg/L), measured in serum. Between these 2 levels are encompassed the lower normal ranges of the other cohorts. Mean ± standard deviation was 765.8 ± 264.8 for the group of no ESRD and 604.9 ± 270.5 for the ESRD group.