Cell survival following ibrutinib and CpG treatment. (A,D) H11, (B,E) BL3750, and (C,F) A20 cells were incubated with serial dilutions of ibrutinib or CpG at concentrations ranging from 0.04 to 10 µM of ibrutinib and 1 to 50 µg/mL of CpG, or with media alone for the indicated time. Cell survival was measured by PrestoBlue staining. (A-C) Ibrutinib; (D-F) CpG.