Transferred T cells from ibrutinib-CpG–treated mice prevent tumor growth in adoptive hosts. (A) Negatively selected CD3, CD8, or CD4 T-cell populations were mixed with H11 tumor cells (100:1 ratio) and co-injected into naïve C57BL/6 mice. (B-D) CD3, CD4, or CD8 T cells, respectively, from naïve mice. (E-G) CD3 T cells from tumor-bearing animals, untreated, ibrutinib-treated, or CpG-treated, respectively. (H-J) CD3, CD4, or CD8 T cells, respectively, from mice treated with the combination of ibrutinib and CpG. (n = 5 mice per group; this experiment was repeated twice with similar results.)