A model for TLR2/6-mediated hypoferremia. Binding of specific TLR ligands to the Toll-like receptors TLR2 and TLR6 downregulates the expression of the cellular iron exporter ferroportin in reticuloendothelial macrophages. As a result, iron that has been recycled from senescent red blood cells fails to be exported into the plasma, promoting the development of hypoferremia.