Reorganization of BET binding following GATA1 complementation. (A) Genome browser tracks showing ChIP-seq signals for the indicated proteins at the mouse β-globin (Hbb) locus. (B) ChIP-seq signal across 4-kb regions centered on GATA1-binding sites ranked from strongest GATA1-binding signal (highest MACS score) to lowest GATA1 signal. (C) Boxplots showing BET reads per kilobase per million (RPKM) at random genomic regions (rand) or GATA1 sites (all, only those at promoters [pro], or only those at candidate enhancers [enh]). Here, we use DNaseI-hypersensitive, H3K4me1-enriched, promoter-excluded sites as enhancers as in Hsiung et al.⁶⁸