Figure 1
Entospletinib shows greater selectivity for Syk than for R406. The blue circle represents Syk. Kinase activity for entospletinib is illustrated on the left, and kinase activity for R406 is illustrated on the right. Entospletinib is Syk-selective (Syk Kd = 7.6 nM, with only 1 other kinase with a Kd < 100 nM). R406 is nonselective (Syk Kd = 15 nM, with 25 kinases with Kd < 15 nM and 54 additional kinases with Kd < 100 nM).
