Morgana is underexpressed in a subgroup of CML Ph⁺ patients. (A) Morgana IHC staining on BM biopsies of representative Morgana normal (cases 7 and 8) and Morgana low (cases 9 and 10) Ph⁺ CML patients. The scale bar = 100 μm. (B) The graph indicates the percentage of Ph⁺ CML patients expressing morgana at normal (84%) and low (16%) levels as assessed by IHC analysis on BM sections (n = 19). (C) Percentages of CD34⁺ BM cells with >2 centrosomes in CML patients at diagnosis, expressing normal or low morgana levels (n = 4 patients per group) and healthy donors (n = 3). The black bar indicates low morgana expression levels. (D) Percentage of aneuploid metaphases in Morgana normal and Morgana low Ph⁺ CML and Morgana low aCML BM cells compared with normal BM cells. The black bars indicate low morgana expression levels. *P < .05.