Megakaryocytes persist in the absence of Aurka. (A-B) Fourteen days after pI-pC treatment, bone marrow cells were isolated from control and knockout mice, erythrocytes were lysed, and cells were stained with CD41 and CD42. Representative (A) flow plots and (B) bar graph with means ± SD are shown; n = 8. (C) Absolute numbers of CD41⁺/CD42⁺ cells in the bone marrow 14 days after pI-pC treatment revealed no significant difference between the WT, Aurka^+/−, and Aurka^−/− samples. Means ± SD are shown; n = 5. (D) Western blot of Aurka levels during THPO-induced megakaryocytic differentiation of murine bone marrow cells. Hsc70 is shown as a loading control. ***P < .001.