MLN8237 selectively induces CD41 expression concomitant with polyploidization. SET2 cells were treated with MLN8237, the cell cycle inhibitors cytochalasin D (Cyto. D), or latrunculin B (Lat. B) for 72 hours and analyzed for (A) DNA content and (B) CD41 expression by flow cytometry. Bar graphs of mean ± SD; n = 3 (MLN8237) and n = 2 (cytochalasin D and latrunculin B). ***P < .001; **P < .01.