Pathophysiological mechanisms per type of VWD. (A) FVIII:C/VWF:Ag vs VWFpp/VWF:Ag for types 1, 2A, 2B, 2M, and 2N VWD. Potential mechanisms include increased clearance (yellow), reduced synthesis (purple), combination of both (green), and other mechanisms (white). (B) Proportion of VWF patients with increased clearance (yellow), reduced synthesis (purple), combination of both (green), and other (white). See Figure 2A-B in the article by Sanders et al that begins on page 3006.