Time to resolution of VOC (primary end point) and component (secondary) end points. (A) Kaplan-Meier plot of time to resolution of VOC, defined as composite primary end point (see “Methods”). Maximum times were 758.1 hours (GMI-1070) and 622.8 hours (placebo). (All subjects achieved this end point; N = 76). (B) Kaplan-Meier plot of time to first ≥ 1.5 cm sustained decrease in VAS pain score and transition to oral analgesia for those achieving this component at any time (N = 52). Maximum times were 307.7 hours (GMI-1070, N = 29) and 281.5 hours (placebo, N = 23). (C) Kaplan-Meier plot of time to documented readiness for discharge for those achieving this component at any time (N = 66). Maximum times were 336.7 hours (GMI-1070, N = 38) and 588.7 hours (placebo, N = 28). (D) Kaplan-Meier plot of time to order for discharge. Maximum times were 758.1 hours (GMI-1070) and 622.8 hours (placebo). (All subjects achieved this end point; N = 76).