Induction of OP inhibits growth of mouse and human leukemic cells. (A) Human leukemic cell lines and normal CD34⁺ cells isolated from cord blood (CB) or peripheral blood (PB) were treated with different concentrations of DCA and cell growth measured by MTT assay. Line graph represents % cell growth of each cell line compared with corresponding untreated control cells with 5 days of DCA treatment. Data represent mean ± SEM. *P < .01. (B) Bar graph depicting % cell growth of murine MLL-AF9 leukemic cells (retroviral and knockin) treated with DCA compared with respective phosphate-buffered saline (PBS)-treated control cells at day 4 posttreatment. (C) Graphic summary of the results depicting regulation of HLF and mitochondrial respiration by Meis1 in MLL-fusion gene leukemia.