Role of Jagged-1 in regulating normal and CML LTHSC growth. (A) Jagged 1 expression in OBs from normal and BCR/ABL mice. (B) Cell cycle, (C) apoptosis, and (D) cell growth of LTHSCs from control and BCR/ABL mice after coculture with OP9 or OP9-Jag1 for 48 hours. (E) Cell cycle, (F) apoptosis, and (G) cell growth of LTHSCs from control and BCR/ABL mice after culture with or without Jag1/Fc immobilized wells. NL, normal.