RNA initiates thrombosis after FeCl₃-induced carotid artery injury. After injection of 8 mg/kg of RNase or DNase, or an equivalent volume of saline, 7.5% FeCl₃ was applied to the right carotid arteries of (A) wild-type (1 × 2-mm filter paper for 1.5 minutes) or (C) HRG^−/− mice (1 × 1-mm filter paper for 1 minute) to induce vascular injury (n = 6-7/group) and blood flow was continuously monitored and data were plotted vs time. Symbols represent the mean, and the bars reflect the standard error (SE). (B,D) Respective TTO data are presented as a scatter diagram, where symbols represent individual values and horizontal lines represent the mean in each of the 3 groups. Values represent mean ± SD; *P < .001 compared with the saline control group (ANOVA, Holm-Sidak method).