Best spleen response. (A) Best percentage change in spleen volume from baseline up to week 24 by MRI. Depicts the maximum percentage of the change in spleen volume from baseline through week 24 for each patient. Each patient has a baseline measurement and at least 1 postbaseline measurement. Patients at or below the 35% threshold horizontal line are spleen-volume responders. (B) Best percentage change in spleen length from baseline up to week 24 by physical examination. Depicts the maximum percentage of the change in spleen length from baseline through week 24 for each patient. Each patient has a baseline measurement and at least 1 postbaseline measurement. Patients at or below the 50% threshold horizontal line are spleen-length responders.