Schematic representation of the microenvironment and agents with the potential of targeting specific CLL pathways. APRIL, a proliferation-inducing ligand; BAFF, B cell–activating factor of the TNF family; BTK, Bruton tyrosine kinase; PD1, programmed death 1 receptor; PI3Kδ, phosphoinositide 3-kinase δ.

Schematic representation of the microenvironment and agents with the potential of targeting specific CLL pathways. APRIL, a proliferation-inducing ligand; BAFF, B cell–activating factor of the TNF family; BTK, Bruton tyrosine kinase; PD1, programmed death 1 receptor; PI3Kδ, phosphoinositide 3-kinase δ.

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