Boolean implications identify mutations strongly linked to changes in DNA methylation. (A) Schematic of process for generating Boolean implications. (B) Examples of HI-HI (hypermethylation) and HI-LO (hypomethylation) implications between mutation and methylation. (C) Summary of the total number of HI-HI (left) and HI-LO (right) Boolean implications with CpG sites from Illumina 450K array for each recurrent mutation in the TCGA AML data set. Each mutation is categorized into 1 of 4 groups (HI-HI, HI-LO, Mixed, or Very Few) according to the predominant numbers of either HI-HI or HI-LO implications. (D) Graph of hypermethylation index (number of HI-HI/number of HI-LO) (left) or hypomethylation index (number of HI-LO/number of HI-HI) (right) for each mutation.