Figure 2
![Figure 2. MCL-1 is essential for recovery of the hematopoietic system from sublethal γ-irradiation. (A) Mice (wild-type or Mcl-1+/−) were subjected to 8 Gy γ-irradiation and their survival monitored (median survival of Mcl-1+/− mice: 11 days; log-rank [Mantle-Cox] test, P < .0001); n = 14 (wild-type), 10 (Mcl-1+/−) mice. Pooled results from 2 independent experiments are shown. (B) Histologic analysis of the bone marrow of wild-type and Mcl-1+/− mice was performed 12 days after γ-irradiation. Representative hematoxylin and eosin (H&E)-stained bone marrow sections (×20 objective, 500 µm scale bar).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/125/21/10.1182_blood-2015-01-621250/4/3273f2.jpeg?Expires=1735529386&Signature=no~4Z~HHYNwhiWysx-NIwNqmP~WxBtyRQtCacmg3XOJwPEVWK7YH8VejbfjZ421z8LU-FQi4dZFTtDV9LLw8Z3gEFl3rAI7DF1b5iSqfSQKkm2ZhE7sWCUCt9cJ8Vsyz4g22p0eHgZtMma-~9GAg8WdS-euUsA5qfvV~6vPJzUKg7VBo8FLiJiRzBxZU7uMyQ1f5VzDv1f5likpJExdshW2I7YU~39T6dTcN3iBGZq8z7QlGaNJjuvfJF27PzDp7x829GE~AR5nSSxd2AZ3SrG-8YeIlmsAPgj8wUAReQapqiy5uUyqHW9rYjdPpiPRK8QZKmLWpBpBYDtEN88xFIg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
MCL-1 is essential for recovery of the hematopoietic system from sublethal γ-irradiation. (A) Mice (wild-type or Mcl-1+/−) were subjected to 8 Gy γ-irradiation and their survival monitored (median survival of Mcl-1+/− mice: 11 days; log-rank [Mantle-Cox] test, P < .0001); n = 14 (wild-type), 10 (Mcl-1+/−) mice. Pooled results from 2 independent experiments are shown. (B) Histologic analysis of the bone marrow of wild-type and Mcl-1+/− mice was performed 12 days after γ-irradiation. Representative hematoxylin and eosin (H&E)-stained bone marrow sections (×20 objective, 500 µm scale bar).
