Enhanced efficacy of D519V/E665V in a TVT injury model. HemA mice were treated with BDD-FVIII or D519V/E665V at the indicated dose 24 hours before TVT. HemA mouse 24-hour survival plotted against the dose. ED₅₀ values obtained for HemA mice dosed with BDD-FVIII or D519V/E665V are displayed, along with their respective chromogenic specific activities (right). Statistical significance (P = .05) was determined using analysis of covariance. Chromo SA, chromogenic specific activity.