Summary of frontline therapy. Asterisk indicates optional. BP, bendamustine-prednisone; CTD, cyclophosphamide-thalidomide-dexamethasone; MPT, melphalan-prednisone-thalidomide; Rd, lenalidomide and low-dose dexamethasone; VCD, bortezomib-cyclophosphamide-dexamethasonemide; VMP, bortezomib-melphalan-prednisone.