Nsg2 and mitochondrial genes are directly targeted by Fbxl10. (A) Fbxl10 ChIP-seq signal at Nsg2 gene regions flanking promoter and TSS in HSCs. Rectangles indicate regions where Fbxl10 bindings are higher in Tg HSCs than in control HSCs (left) and the bar graph demonstrates relative ChIP/Input ratio [ChIP DNA (ppm) divided by Input DNA (ppm)] in the indicated regions (right). (B) CpG sequences detected in Nsg2 gene regions flanking promoter and TSS, which was sought using sequence manipulation suite program.²⁶  Fbxl10 was highly recruited to the region +1991 to +2190 of Nsg2 gene in Tg HSCs, as shown in panel A. (C) Fbxl10 ChIP-seq signal at OXPHOS genes (Ndufs6, Ndufb2, and Uqcrfs1) regions flanking promoter and TSS. Rectangles indicate regions where Fbxl10 bindings are higher in Tg HSCs than in control HSCs (left) and the bar graphs demonstrate relative ChIP/Input ratio in the indicated regions (right).