Tet2 loss influences hematopoietic differentiation within the myeloid progenitor compartment of Jak2V617F mice but is insufficient to induce leukemic transformation. (A-C) White blood cell (WBC) count, hematocrit, and platelet (PLT) count of age-matched WT, Tet2^null, Jak2^VF, and Jak2^VF/Tet2^null mice 24 to 30 weeks old (mean ± SEM; n = 4 in each group). (D-F) Relative frequency of common myeloid progenitor (CMP), granulocyte macrophage progenitor (GMP), and megakaryocyte erythroid progenitor (MEP) cells in bone marrow from age-matched WT, Tet2^null, Jak2^VF, and Jak2^VF/Tet2^null mice (mean ± SEM; n = 4 in each group). (G-I) Histopathologic sections of bone marrow from representative WT, Tet2^null, Jak2^VF, and Jak2^VF/Tet2^null mice (original magnifications ×10 for G1-G4, ×40 for H1-H4, and ×100 for I1-I4; H&E stain).