VWF multimer distribution in plasma and platelets and the rate of thrombus formation in mesenteric arterioles after injury. (A) The multimer distribution in plasma (lanes 1-3) and in platelet lysate (lanes 4-6) of WT, KO, and TG mice, as indicated. (B) The rate of thrombus formation measured by the accumulation of rhodamine 6G-labeled platelets and leukocytes as a function of time (minutes:seconds) in the mesenteric arterioles of WT, KO, and TG mice (CAST/Ei) after being injured with a topical application of 10% FeCl₃. (C) Comparison of the rate of thrombus formation in the mesenteric arterioles between Adamts13^−/− CAST/Ei and Adamts13^−/− C57BL/6 mice. The data represent the means and standard errors of the means of 3-5 mice in each group, as indicated.