Location of the independently associated nonsynomymous variants across the functional domains of ADAMTS13. Asp187His is rs148312697, Ala732Val is rs41314453, Gly982Arg is rs36222275, and Arg1060Trp is rs142572218. S indicates the signal peptide, and P indicates the propeptide. Thrombospondin type 1 repeats 1 to 8 are shown as circles. Cys-rich indicates the cysteine-rich domain, and CUB indicates the C1r-C1s, urinary epidermal growth factor, and bone morphogenetic protein domains.