Crystal structures of Fab 72 and MEDI2452 in complex with ticagrelor. Fab 72 (pdb id 5alc) (A) and MEDI2452 (pdb id 5alb) (B) are shown in ribbon representation, with amino acid residues within 7 Å from ticagrelor shown as sticks. Some main-chain atoms were omitted for clarity. Light chains are shown in beige; heavy chains in light blue; CDR3s from both chains in green. V_H CDR3 could not be modeled in the Fab 72 structure, and a tentative location is drawn as a dashed line. The orange arrow indicates the shift in V_L CDR3 observed in MEDI2452 compared to Fab 72. Residues are numbered following the Kabat scheme and are prefixed with L or H to indicate light or heavy chain, respectively.