The frequency of involvement by chronic GVHD varies across organs and sites and is higher after HCT with mobilized blood cells as compared with marrow. (A) The most frequently involved organs and sites are the skin, mouth, eyes, gastrointestinal tract, and liver.3 (B) Chronic GVHD can affect all layers of the skin. Photographs of each manifestation in italic may be found in the supplemental Data, available on the Blood Web site. Artwork by Delilah Cohn, MFA, CMI, used with permission.