A model of HTLV-1–induced leukemogenesis. Longitudinal accumulation of genetic and epigenetic abnormalities in long-lived HTLV-1–infected TSCM cells leads to the development of ATL. TN, naïve T cells; TCR, T-cell receptor.

A model of HTLV-1–induced leukemogenesis. Longitudinal accumulation of genetic and epigenetic abnormalities in long-lived HTLV-1–infected TSCM cells leads to the development of ATL. TN, naïve T cells; TCR, T-cell receptor.

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