The shortest isoform of LSD1 modifies the gene expression program in favor of increasing the self-renewal and T-cell priming of HSPCs. (A) We performed microarray-based gene expression profiling in Lin⁻/Sca-1⁺ bone marrow cells from LSD1 transgenic (line 6 and 3) and control mice. A pairwise comparison of 39 000 genes is shown with signal intensities in both axes. (B) Gene ontology enrichment analysis for genes whose expression was altered more than twofold in line 6 (Bi) and line 3 (Bii) of LSD1 transgenic mice compared with control mice (P < .05 with an FDR threshold of 0.05). (C) Examples of genes whose expression was altered in line 3 and line 6 of LSD1 transgenic mice compared with control mice in 3 categories (Hox family, hematopoietic cell lineage markers, and cell signaling-related). FDR, false discovery rate.