LSD1 transgenic mice show the focal hyperplasia of lymphocytes but do not develop lymphoid malignancies for up to 12 months of observation. (Ai) Representative photographs of the spleen and thymus from 2 lines of LSD1 transgenic and age-matched (10-18 weeks) control mice and their histologic sections. (Aii) Genomic DNA was extracted from thymocytes of LSD1 transgenic and B6J control mice, and subjected to PCR analysis for TCRβ rearrangement. M, molecular size marker. (B) The actual weights of thymus and spleen from 12-week-old mice. The means ± SD (bars) of 5 independent samples are shown (*P < .05). (C) Bone marrow mononuclear cells (i) and thymic cells (ii) were subjected to flow cytometric analysis for the expression of the indicated lineage markers. The means ± SD (bars) of 3 independent experiments performed between 10 and 12 months of age. P values were determined by 1-way ANOVA with the Bonferroni post hoc test.