Inhibition of Syk by R788 decreases cGVHD in a murine BO model. (A) Day-56 pulmonary function tests on mice treated with 30 mg/kg R788 twice daily from days 28 to 56. (B) GVHD pathology scores from the lungs of mice on day 60. (C) Number of GCs present in situ in spleens of mice. (D) Frequency of GC B cells (gated on CD19⁺GL7⁺CD95^hi) present in the spleens of transplanted mice on day 60. (E-G) Frequency of CD11c cells expressing CD80, CD86, and MHC class II in the spleens of transplanted mice on day 60. *P < .5; **P < .01; ***P < .001. Error bars represent SEM; representative data from 3 independent experiments with n = 8 per group.