Experiment outline and results of the shRNA screen. (A) An overview of the experimental strategy. shRNAs targeting different genes are exemplified in brown, red, and blue. (B) Waterfall plot (ii) showing all shRNAs recovered with >100 reads in the day 0 sample. The y-axis depicts the z score for the comparison of the individual shRNA abundance between day 0 and day 9. Negative z scores refer to depleted genes; positive z scores refer to enriched genes. A zoomed-in version of the negative z scores (i) depicts the shRNAs targeting the 12 candidate genes. Vertical lines refer to the position of the individual shRNAs. Corresponding gene abbreviations are given to the right of the plot.