Extramedullary hematopoiesis and splenomegaly in Dnm2^fl/flPf4-Cre mice. (A) H&E staining of Dnm2^fl/fl and Dnm2^fl/flPf4-Cre spleens. Sections shown are representative of 5 mice for each genotype. Bars represent 20 µm. (B) Dnm2^fl/fl and Dnm2^fl/flPf4-Cre spleen MK counts (mean ± SEM; n = 5 in each group; ***P < .0001). (C) Spleen CFUs in Dnm2^fl/fl and Dnm2^fl/flPf4-Cre mice (mean ± SEM; n = 6 in each group; ***P = .0008). (D) Dnm2^fl/fl and Dnm2^fl/flPf4-Cre spleen sections. Sections shown are representative of 15 mice for each genotype. (E) Spleen/body weight ratios of Dnm2^fl/fl and Dnm2^fl/flPf4-Cre mice (mean ± SEM; n = 15 in each group; ***P < .0001).