Human CLL cells roll, stick, and crawl within mouse LN HEVs in vivo. (A) Visualization of the mouse inguinal LN microcirculation by intravital microscopy. (B) Rolling and sticking of human CLL cells within mouse LN HEVs. (C) CLL cells from patients with bulky disease roll slower within LN HEVs. (D) Two-photon microscopy time-lapse images showing CLL cells from patients with bulky disease (arrowheads) crawling on HEV endothelium. See the complete Figure 3 in the article by Lafouresse et al that begins on page 1336.